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KMID : 0613320090150020130
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Journal of the Korean Bone and Joint Tumor Soceity
2009 Volume.15 No. 2 p.130 ~ p.137
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STAT3 is Activated in a Subset of Benign and Malignant Chondroid Tumors
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Park Hye-Rim
Park Yong-Koo
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Abstract
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Purpose: STAT3 is an oncogene that regulates critical cellular processes, and its constitutive activation has been demonstrated to correlate with biological and clinical features in many types of human malignancy.
Materials and Methods : In this study, STAT3 activation was assessed in variable benign and malignant chondroid tumors in bone by immunohistochemistry using a monoclonal antibody specific for tyrosine705-phosphorylated STAT3 (pSTAT3tyr705).
Results: Among conventional chondrosarcomas (n=17), three cases(50%) of grade III chondrosarcomas were pSTAT3-positive. All grade I and II chondrosarcomas were pSTAT3-negative. This pSTAT3 positivity according to the histologic grade was statistically significant (p=0.0432). Two cases(50%) of clear cell chondrosarcomas were pSTAT3-positive. Six cases (50%) among 12 benign chondroid tumors(6 enchondromas, 3 chondroblastomas, and 3 chondromyxoid fibromas) were also pSTAT3tyr705-positive.
Conclusion: In conclusion, STAT3 activation is associated with higher tumor grade in conventional chondrosarcomas. Our results suggest that STAT3 is activated in a subset of benign and malignant chondroid tumors, and may support the extension of the cancer stem cell hypothesis to include tumors of cartilaginous lineage.
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KEYWORD
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Chondroid tumors, STAT3, Immunohistochemistry
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